Gene Therapy To Restore And Improve Vision

Reduced vision, as well as blindness my exist for somebody for several reasons. Treatment depends on just what the cause is, and the way effective treatments will probably be. Conventional, non invasive treatment happens to be eye-glasses, or contact lenses to fix visual problems. Over time, improved eye glass lenses and contacts have evolved that reduce glare, eliminate unwanted wavelengths of light, improve depth perception, and address many environmental issues.

More recently, there are new developments in the medical therapy for visual impairments. For example, Avastin a drug that was originally meant to treat Colo-rectal cancer has been seen as to improve the vision in patients with Macular Degeneration, Diabetic Retinopathy and also other vascular related retinal diseases. Non steroidal anti inflammatory drugs can help to eliminate retinal inflammation, and cyst formations. New drugs have been developed to treat infections more affectively.

A major challenge continues to be therapeutic options for genetic and congenital disorders. These diseases arise from the inside the person, and for that reason pose limited treatments. The future seems to be gene therapy. Recent numerous studies performed with the Scheie Eye Institute in Philadelphia using gene therapy have dramatically improved patient?s vision from detecting hand motion to reading letters with an eye chart. These tests were performed on individuals struggling with a congenital disease called Leber?s Congenital Amaurosis. The study was then published in the New England Journal of Medicine. This particular eye disease comes from a mutation in the RPE 65 gene. This mutation prevents the gene from producing a protein required within the manufacturing with the retinal pigment epithelium. This protein is essential to the retinal tissue to absorb and process the sunshine into vision.

The treatment included injecting a normal RPE 65 gene directly into the retina. Two weeks following injection, all of the patients demonstrated improved vision. In addition, all participants became more understanding of light. As a result in the increase in acuity, there is a concomitant decline in abnormal eye movements which further increased the eye?s ability to see.

While these clinical investigations were performed on people with some congenital disorder, it gives hope to others with genetic conditions that assistance is on how. With any luck, retinal disease is going to be a thing in the past as these treatment modalities improve.